Anatomy Lab HP // Physiology Lecture HP // Student Resources HP
Physiology Lecture Unit Three (C19 - C23)
Unit Three Lecture Objectives // Dictionary of Pronunciation // Medical Dictionary
 
  Chapter 19: The Cardiovascular System / Blood
 
    Lecture Slides /Matched to Learning Objectives
       
   
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Hemopoiesis: Erythropoiesis and Leukopoiesis
    * Structure and Functions of the Formed Elements
    * Hemostasis
   
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Blood Typing
       
   
Homework Assignments / Matched to Learning Objectives / Highly Recommended
       
   
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    * Audio Review / Blood
       
    Study Guides / Matched to Learning Objectives / Not Required
       
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    * C19 HL Questions
       
    Articles of Interest / Optional / Not Required
       
    * HS Football Player Dies From Ruptured Spleen
   
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    * Articles of Interest / Archival
       
    Topics of Interest / Not Learning Objectives / Not Required
       
    * Pathophysiology: Blood and Circulatory System
       
 
  Chapter 20: The Cardiovascular System / The Heart
 
    Lecture Slides /Matched to Learning Objectives
       
   
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Function of the Heart
   
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The Cardiac Cycle, Cardiac Output, and Cardiac Regulation
       
    Homework Assignments / Matched to Learning Objectives / Highly Recommended
       
   
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    * Heart: CT Scan of Ventricular Blood Vessels
    * Heart Blockage and Heart Attack
   
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    * Audio Review / Anatomy of the Heart
       
    Study Guides / Matched to Learning Objectives / Not Required
       
    * C20 Study Guide
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    Articles of Interest / Not Required
       
    * Commotio Cordis - Heart Trauma Causes Rare Disruption of T Wave Repolarization
    * Cardiomegaly (Enlarged Heart)
    * Articles of Interest / Archival
       
    Topics of Interest / Not Learning Objectives / Not Required
    * Pathophysiology of the Heart
 
  Chapter 21: Blood Vessels & Hemodynamics
 
    Lecture Slides /Matched to Learning Objectives
       
   
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Introduction to Blood Vessels
   
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Blood Pressure and Blood Flow
   
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Special Circulatory Routes
       
    Homework Assignments / Matched to Learning Objectives / Highly Recommended
       
   
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    * Audio Review / Physiology of the Cardiovascular Sysem
       
    Study Guides / Matched to Learning Objectives / Not Required
       
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    * C21 Study Guide with HLQ
       
    Articles of Interest / Not Required
       
    * Articles of Interest / Archival
       
    Topics of Interest / Not Learning Objectives / Not Required
       
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  Chapter 22: The Lymphatic and Immunity
 
    Lecture Slides /Matched to Learning Objectives
       
   
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Introduction to the Lymphatic and the Immune Systems
   
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Lymphatic Cells VS Lymphatic Tissue VS Lymphatic Organs
   
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Innate Immunity: Defensive Barriers and Non-Speific Resistance
   
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Adaptive Immunity (also called Acquired Immunity)
   
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Four Types of Adaptive Immunity - Classification Model
   
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Antibodies Structure and Function
   
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Hypersensitivity
   
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Autoimmune and Immunodeficiency Diseases
       
    Homework Assignments / Matched to Learning Objectives / Highly Recommended
       
     

When you need to learn a complex subject, it helps to first study a simpler model.. The first four videos are ment to be "a simpler model" about human immunity. The other videos cover specific mechanisms about the innate and adaptive immune systems.

So to begin, our immune system has two divisions: innate immunity and adaptive immunity. All animals (invertebrates and vertebrates) possess innate immunity, a type of non-specific resistance to pathogens. An innate immune response will attack indiscriminately microbes and other pathogens. Vertebrates have an additional and more powerful immune response called adaptive immunity. This will destroy specific pathogens and then make memory cells to recognize the same pathogen in the future. Upon a second exposure to the pathogen, the memory cells respond so rapidly that you do not even know you were infected. ..

At the bottom of the page are four lectures sponsored by HHMI and presented by "world leaders in the field of immunology". These lectures will allow the curious student to learn from the most knowledgeable scientist now working on advanced research in immunology.

 
     
   
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Lymphatic System's Role in Immunity
   
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The Inflammatory Response
   
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    * Adaptive Immunity (HHMI):
     
   
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Non Specific Resistance
   
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Natural Killer Cells - Video
   
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Interferon Anti Viral Activity
   
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Activation of Complement
   
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Agglutination
     
   
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Clonal Selection
    * Helper T Cell Activation / Mechanism (HHMI) // View the animation to see how one type of immune cell—the helper T cell—interprets a message presented at the surface of the cell membrane. The message is an antigen, a protein fragment taken from an invading microbe. A series of events unfolds that results in the production of many clones of the helper T cell. These identical T cells can serve as a brigade forming an essential communication network to activate B cells, which make antibodies that will specifically attack the activating antigen.
   
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    * Activation of Helper T Cells and Cytotoxic T Cells (Illustration)
   
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Cell Dependent Antigens
   
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Antigen Processing and Presentation / Macrophage and B Cells
   
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Antigen Presenting Cells
   
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Antigen Processing
   
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Antigenic Determinants
     
   
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Antibodies
   
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Antibody Diversity
     
   
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    * Polio virus
   
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    * Delayed Type IV Hypersensitivity
    * Immunization Vacination Schedule
   
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    * Cytotoxic T Cells Attacking Infected Cell
     
   
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    * Cancer: Using Immunotherapy to Kill Cancer Cells
      > Check Point Therapy - Dendritic Cell Vacines - CAR T Cells // SA Illustration
      > Synthetic Immune Cells - SA Illustration
      > How Dendritic Cells Activate T Cells - Illustration
      > PD-1 As Cytotoxic T Cell "Suicide Switch" - Leads to New Immuno-Cancer Therapy
      > Program Cell Death Receptor
      > Blocking PDL-1
      > PD-1 and PDL-1 Video ---Very Good!
      > Review the Four New Immunooncology Therapies -- Also Very Good!
      > How the Immune System Sees and Destroys Tumors, Dr. Jeffrey Weber, MD, PhD (90 minutes)
       
     
    * Sloan Kettering Scientists Engineer Immune System to Identify and
Destroy Leukemia and Prostate Cancer Cells (6 min)
     
    * Audio Review / Lymphatic System
    * Audio Review / Immune System
    * Audio Review / Stress
       
    Study Guides / Matched to Learning Objectives / Not Required
       
    * C22 Study Guide / Part A - The Lymphatics System (with HLQ)
    * C22 Study Guide / Part B - Non-specific Resistance & Adaptive Immunity - with HL Questions
       
    Articles of Interest / Not Required
       
    * Future of Medicine - Living Curcuits
    * Neuroimmunology: The Mind Body Connection.
   
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New Science - Synthetic Immune Cells ( Article with image)
    * Cytotoxic T Cell Activation (Wiki)
   
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PDL-1 Check Point Inhibitors
    * Zika - An Emerging Disease: This is a good example of what happens when the world ignores an emerging disease until it becomes a potential global pandemic. The catastrophe is only further fueled by the USA congress who now stay on their summer vacations while refusing to provide necessary funding for scientific research necessary to solve the Zika problem. Unfortunately, history often repeats its failures!
    * Articles of Interest / Archival - See Immunology
       
    Topics of Interest / Not Learning Objectives / Not Required
       
    * Understanding Pathogens and the Flu Virus
       
      The four lectures below, Immunity: Friend or Foe, where sponsored by the Howard Hughes Medical Institute. Each one hour lecture covers an important topic related to our immune system.
       
   
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Lecture 1: How Cells Create Trillions of Receptors from a Few Hundred Parts
by John Kappler, PhD
   
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Lecture 2: How the Immune System Detects Invaders
   
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Lecture 3: How the Host Avoids "Friendly Fire" by Dr. Kappler, PhD
   
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Lecture 4: Stalking the Elusive Pathogen by Dr. Phillippa Marrack, PhD
       
 
  Chapter 23: The Respiratory System
 
    Lecture Slides /Matched to Learning Objectives
   
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Respiratory System Learning Objectives
   
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Respiratory System Regulation Learning Objectives
       
    These Lecture Slides Are a More Comprehensive Review of Respiratory System (Not Required)
   
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Introduction to the Respiratory System
   
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Gas Exchange and Transport
       
    Homework Assignments / Matched to Learning Objectives / Highly Recommended
       
   
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Respiratory Volumes & Spirometry - Excellent Presentation! (Video)
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Transport of Respiratory Gases (Video)
    * Audio Review / Respiratory System
       
    Study Guides / Matched to Learning Objectives / Not Required
       
   
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    Articles of Interest / Not Required
       
    * Lung Function Test
   
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    * Hiccups
    * Articles of Interest / Archival
       
    Topics of Interest / Not Learning Objectives / Not Required
       
    * Pathophysiology: Respiratory System
       
Lecture: Unit 1 - Unit 2 - Unit 3 - Unit 4 ////////////Lab: Unit 1 - Unit 2 - Unit 3 - Unit 4